Carolyn's Blog

What is amylose? Amylose synthesis itself is simple, and is the linear chains formed through processive elongation by  a single enzyme, the Granule Bound Starch Synthase ( GBSS). GBSS is the glucosyltransferase responsible for elongating polymers and was the only protein known to be required for it’s biosynthesis. The Protein Targeting to Starch (PTST) is also specifically required for amylose synthesis in Arabidopsis. PTST is a plastidial protein possessing an N-  terminal coiled coil domain, and a C- terminal carbohydrate…

Read More Read More

Redefining Reality is inclusive of the genome project, and all the hacking that was done by some. All I know is I saw kids being abused and I spoke for 8 years. Now I walk away as I have completed my job. Carolyn d Hogarth

Edwin Abbott Abbott’s Flatland is the story of a two-dimensional universe as told by one of its inhabitants, a square who is introduced to the mysteries of three-dimensional space by a sphere. Written in large part as a satire on Abbott’s closed minded Victorian contemporaries, Flatland ably demonstrates the absurdity of those unwilling to admit their own ignorances, even when they scoff at the ignorance of others. Flatland is, whether intended or not, more than satire. (Mar 25, 2017.)  …

Read More Read More

If one judges Love by it’s effects, it is more hate than love. Is there no place better to Love than on earth? Just Love each other…That is all….     United We Stand and Divided We Fall  

Transthyretin cardiac amyloidosis (ATTR – CM) is a heart disease that occurs when something goes wrong with a protein produced by the Liver. The organs mostly affected by amyloidosis are the kidney, liver, and heart. Hereditary Amyloidosis (familial amyloidosis) is an inherited disorder often effecting the nerves  in the heart, kidney and it most commonly occurs when a protein made by the liver is abnormal.  It commonly effects eyes and can be triggered by a chronic disease, infection or cancer,…

Read More Read More

You are my hiding place, and will protect me from trouble,  and will sing me songs of deliverance. Psalms 32:7   Amen, Amen Amen

Transthyretin Amyloidosis are mutated forms of Amyloid fibrils  that affect the heart, the veins, oxygen flow, blood flow, kidneys, brain, liver, pancreas, and can affect life itself. The accumulation of amyloid deposits disturb normal functioning of organs. Some form life threatening diseases. They can cause abnormal heart rhythms, fatigue, shortness of breath, fainting, dizzy when standing, tingling in fingers and toes, swelling of feet, foamy urine, excess protein, easy bruising and enlarged tongue, and marks or bumps on your skin…

Read More Read More

The National Institute of Health covid spike protein enhances Ace 2 activity and is high homologous to covid 19 and Sars 2 as both use Ace 2 as their entry receptor. Further structural studies demonstrate that both Sars 2 and covid 19 used their Spike protein RBD to interact with Ace 2 binding modes. The Ace 2 receptor serves as the gateway for the entry of the virus inside the body. The virus replicates and simultaneously hampers other organs expressing…

Read More Read More

I will start with one area of the neuron because I have to start somewhere to explain what I am talking about when I say, “what is neuronal degeneration?” Myelin sheath is the spiral wrapping around axons that help speed and insulate the nerve impulses. Most neurons have just one main axon or pathway for sending neurite or called an “axonal processes” or nerve fibre; it is much longer and thicker than the dendrite. Each neuron has it’s own immensely…

Read More Read More

The post-infection of COVID-19 includes a myriad of neurological symptoms including neuron – degeneration. Protein aggregation in the brain can be considered as one of the important reasons behind the neuron – degeneration. SARS-CoV-2 Spike S1 protein receptor binding domain (SARS-CoV-2 S1 RBD) binds to heparin and heparin binding proteins.  (By burying these basic regions, heparin can be expected to hinder the binding of HSPGs, reducing the amount of SARS-CoV-2 that can tether to the cell surface, thus decreasing the…

Read More Read More